Lydia Mosi, PhD | Department of Biochemistry, Cell and Molecular Biology

Office Room Number

S10

Prof. Lydia Mosi

Academic Appointment

Assossiate Professor of Cell and Molecular Biology

lmosi@ug.edu.gh

Education

2004 - 2009 PhD University of Tennessee, Knoxville USA
1999 - 2003 BSc Hons (Zoology and Biochemistry), University of Ghana, Legon

Summary of Research Interests

Neglected tropical skin diseases
Non-tuberculous mycobacterial infections
Antimicrobial resistance
Infectious diseases
Molecular Genetics.

Research Interest

My primary research focus is Buruli ulcer, a necrotizing skin disease caused by Mycobacterium ulcerans. My lab exploits multidisciplinary approaches, insilico genomics, and functional laboratory studies to investigate gaps in transmission to identify the niche of MU and other mycobacteria in the natural environment; and the development of rapid diagnostic and intervention strategies for Buruli ulcer disease. Additionally, I work on characterizing secondary microbial infections in Buruli ulcer lesions and determining antimicrobial resistance in microbes from patient and environmental samples. I have extensive experience in both lab and fieldwork.

Courses taught

BCMB 203 Principles of Biochemical Techniques
BCMB 212 Veterinary Biochemistry III
BCMB 208 Veterinary Biochemistry II
BCHM 303 Separation Methods
BCHM 305 Analytical Techniques
BCMB 403 Molecular Biotechnology & Applications
BCMB 406 Molecular Genetics
BCMB 410 Seminar Presentation, and Scientific Writing
MCBI 601 Bacterial and Viral Infections
MCBI 603 Experimental Microbiology
BCMB 603 Advanced Molecular Biology

Selected Publications

Ayerakwa EA, Abban MK, Isawumi A, Mosi L. Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors. Future Sci OA. 2023 Mar 23;9(3):FSO845. doi: 10.2144/fsoa-2022-0044. PMID: 37026027; PMCID: PMC10072065.
Isawumi A, Abban MK, Ayerakwa EA, Mosi L. Calcium Potentiated Carbapenem Effectiveness Against Resistant Enterobacter Species. Microbiol Insights. 2022 Oct 28;15:11786361221133728. https://doi.org/10.1177/11786361221133728. PMID: 36325109; PMCID: PMC9619913.
Kwaffo YA, Sarpong-Duah M, Owusu-Boateng K, Gbewonyo WS, Adjimani JP, Mosi L. Natural antioxidants attenuate mycolactone toxicity to RAW 264.7 macrophages. (2021) Exp Biol Med (Maywood).May 26:15353702211015628. https://doi.org/10.1177/15353702211015628.
Gyamfi E, Narh CA, Quaye C, Abass A, Dzudzor B, Mosi L. Microbiology of secondary infections in Buruli ulcer lesions; implications for therapeutic interventions. (2021). BMC Microbiol. Jan 5;21(1):4. https://doi.org/10.1186/s12866-020-02070-5.
Abana D, Gyamfi E, Dogbe M, Opoku G, Opare D, Boateng G, Mosi L. (2017). Investigating the virulent genes and antibiotic susceptibility patterns of Vibrio cholerae O1 in environmental and clinical isolates in Accra. BMC Infect Dis. Jan 21;19(1):76.
Konan, D. O., L. Mosi, G. Fokou, C. Dassi, C. A. Narh, C. Quaye, J. Saric, N. N. Abe, and B. Bonfoh. (2019). "Buruli ulcer in southern Côte d'Ivoire: dynamic schemes of perception and interpretation of modes of transmission." J Biosoc Sci 51 (4):520-533. https://doi.org/10.1017/S0021932018000317.
Dassi, C., L. Mosi, C. A. Narh, C. Quaye, D. O. Konan, J. A. Djaman, and B. Bonfoh. (2017). Distribution and Risk of Mycolactone-Producing Mycobacteria Transmission within Buruli Ulcer Endemic Communities in Cote d'Ivoire. Trop Med Infect Dis 2 (1). https://doi.org/10.3390/tropicalmed2010003.
Dassi C, Mosi L, Akpatou B, Narh C. A., Quaye C., Konan D. O., Djaman J. A. and Bonfoh B. (2015). Detection of Mycobacterium ulcerans in Mastomys natalensis and potential transmission in Buruli ulcer endemic areas in Côte d'Ivoire Medical Sciences. Mycobact Dis, 5: 184 DOI: https://doi.org/10.4172/2161-1068.1000184
Narh, C. A, Mosi L., Quaye C, Dassi , Konan D. O., Tay S. C. K, de Souza D. K., Boakye D. A, Bonfoh B. (2015) Source tracking Mycobacterium ulcerans infections in the Ashanti region, Ghana. PLoS Negl Trop Dis. Jan 22;9(1):e0003437.
Narh C. A. , Mosi L., Quaye C., Tay S.C.K, Bonfoh B., de Souza D. K.. (2014). Genotyping tools for Mycobacterium ulcerans- drawbacks and future prospect. Mycobact Dis; 4(2):1000149.
Mosi L., Mutoji N., Basile F. A., Donnell R., Jackson K. L., Spangenberg T., Kishi Y., Ennis D., and Small P. L.C. (2012) Experimental infection of Medaka (Oryzias latipes) with Mycobacterium ulcerans: A model for transmission, pathogeneses and toxicity to fish. Microb. and infect.; 14(9):719-29.
Mosi L, Williamson H, Wallace JR, Merritt RW, Small PL. (2008). Persistent association of Mycobacterium ulcerans with the West African predaceous insect, Belostomatidae. Appl Environ Microbiol.; 74(22):7036-7042.