The School of Nursing was first established as a Post Basic Nursing institution in 1963 as a World Health Organisation (WHO) project at request of the Ministry of Health. It then focused on preparation of Diploma awarded Nurse Tutors for basic nursing training institutions. Further the School also focused on certificate courses in Nursing Management in July 1970 and diploma courses in Nursing Service Administration in 1971.
In 1980, the degree programme began and the designation of the Post-Basic Nursing Department changed to Department of Nursing with a wholly Ghanaian staff and placed under both the Faculties of Science and Social Studies. In July 15, 2003, the Department was upgraded into a School and made a constituent of the College of Health Sciences by the University Council. The School was departmentalised into only (5) five units:

Mental Health Nursing
Public Health Nursing
Maternal and Child Health Nursing
Adult Health Nursing
Research, Education and Administration.

The graduate programme began as a collaboration between the School and its counterpart at the University of Alberta, Canada in 2000.
Master of Philosopy (MPhil) – 2000
Master of Science (MSc) – 2005

Beginning from the 2010/2011 Academic Year, the School has introduced specialty options into its BSc programme. The School’s name was changed to School of Nursing and Midwifery (SONM) in the 2016/2017 academic year with the establishment of five academic departments and these include:

Department of Mental Health Nursing
Department of Community Health Nursing
Department of Maternal and Child Health Nursing
Department of Adult Health Nursing
Department of Research, Education, and Administration.

Past Heads
Dr. Rae Chittick                           1963 – 1969
Ms. Ayodele Akiwumi                1969 – June, 1981
                                                         Dec, 1981 – Sept, 1985
                                                         Oct, 1988 – Sept, 1991
                                                         Oct, 1993 – Sept, 1995
Mrs. Margaret Osei-Boateng        June – Dec, 1981
                                                         Oct, 1985 – Sept, 1988
                                                         Oct, 1991 – Sept, 1993
                                                         Oct, 1995 – Sept, 1996
Joana Larteley Laryea                 1997 – 1999
Ms. Bernice Goka                         1999

Past Deans        
Dr. Mary Opare                             1999 – 2006
Prof. Onike P. Rodrigues            2006 – 2009
Prof. Ernestina S. Donkor           2009 – 2017