BCMB 301: Intermediary Metabolism

Carbohydrates: Digestion of carbohydrates, glycolysis and fate of pyruvate in different organisms; tricarboxylic acid (TCA) cycle; pentose phosphate pathway and fate of reduced coenzymes; catabolism of monosaccharides other than glucose; gluconeogenesis, Calvin Benson cycle, Cori cycle, glyoxylate cycle; glycogenesis and glycogenolysis; regulation of carbohydrate metabolism; Diseases of carbohydrate metabolism.
Lipids: Digestion of triacylglycerols; the different lipases (lipoprotein lipase, hormone-sensitive lipase); fate of glycerol; beta-oxidation of fatty acids; fate of products (acetyl and propionyl CoA, ketone bodies, reduced coenzymes); synthesis of fatty acids triacylglycerol, cholesterol; regulation of metabolism.
Amino acids: Digestion of proteins, transamination, deamination and decarboxylation of amino acids and the fate of ammonia (urea cycle) and carbon skeleton; metabolism of specific amino acids (aromatic and sulphur-containing amino acids); synthesis of amino acids; in-born errors of amino acid metabolism; regulation of metabolism.
Energetics: Free energy and biochemical reactions (spontaneity, anabolic and catabolic reactions); metabolic reactions and ATP; energy of hydrolysis of ATP, ADP and phosphorylation products; ATP production (substrate level and oxidative phosphorylation, photophosphorylation, C3, C4); coupling reactions; uncoupling agents.