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Rev. Prof. Isaac Julius Asiedu-Gyekye

Rev. Prof. Isaac Julius Asiedu-Gyekye
Ag. Dean
ijasiedu-gyekye@ug.edu.gh

Academic Qualifications

  • PhD- (Pharmaceutical Sciences) Pyatigorsk Pharmaceutical Academy
  • MSc Pharm- Pyatigorsk Pharmaceutical Academy

Area of Specialization

  • SAFETY AND EFFICACY OF NATURAL PRODUCTS
  • NON-COMMUNICABLE DISEASES
  • HYPERTENSION
  • ASTHMA

Courses Taught Currently

Whole Pharmacology Programme in Basic and Applied Pharmacology in the University of Ghana Medical School,University of Ghana School of Pharmacy, School of Verterinary Medicine, School of Nursing and School of Allied Health

Research Interests
Safety and efficacy assessment of natural products used to manage non-communicable diseases.

On-Going Research

  • Safety And Efficacy Studies
  • Safety assessment of unsweetened natural cocoa powder and its organoprotective effects during artemether-lumefantrine administration.
  • Pharmacodynamic studies on the mechanisms of action of natural products (the role of nitric oxide).
  • Study Into Anticancer Potentials Of Herbal Preparations
  • Cytotoxic, mutagenic and DNA modulatory properties selected medicinal plants

Most Recent Publications

  • Oussou N.J-B., ASIEDU-GYEKYE I.J., Bla K.B., Kouakou K.L., Yapi H.F., Yapo A.F., Ehile E.E., Yapo A.P. (2015) Evaluation of bio-tolerance of the ethyl acetate fraction from Lophira lanceolata (Ochnaceae) leaves in rats. American Journal of Bio-Pharmacology and Biochemistry and Life Sciences, 4(2), 80-92.

  • Banga N.B., Gnangoran B.N., Sarkodie J.A., Dosso K.,  Kretchy K.I.A., Amoateng P., ASIEDU-GYEKYE I.J., Owusu D.O., Nyarko A.K., and Yapo A.P. (2015). Alternative to Conventional Diabetic Management: The Antihyperglycaemic potential of an Ethyl Acetate Fraction Extract of Holarrhena floribunda. European Journal of Medicinal Plants, 8 (4), 175-189. ISSN: 2231-0894.

  • Adjei S., Amoateng P., Osei-Safo D., Sasu C., N'guessan B.B., Addo P., ASIEDU-GYEKYE I.J. (2015). Sub-acute toxicity of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L) Gaertn in rats. International Journal of Green Pharmacy 8 (4), 271-274.

  • ASIEDU-GYEKYE I.J., Seidu M.A., Awortwe C., Nyarko A.K. (2014). Preliminary Safety assessment of polyhexamethylene guanidine hydrochloride, International Journal of Toxicology, DOI: 10.1177/1091581814553036. 

  • ASIEDU-GYEKYE I.J., Frimpong-Manso S., Awortwe C., Antwi D.A., Nyarko A.K. (2014). Micro and Macro elemental composition and safety evaluation of the nutraceutical Moringa oleifera leaf and its safety evaluation, Journal of Toxicology, vol. 2014, Article ID 786979, 13 pages, 2014. doi:10.1155/2014/786979.

  • Adjei S., Amoateng P., Osafo D., Ahedo B., Banga K.B.N., Addo P., ASIEDU-GYEKYE I.J. (2014). Biochemical and haematological changes following an acute toxicity study of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L) Geartn in male Sprague-Dawley rats, Journal of Medical and Biomedical Science,.3(1), 31-37.

  • Sarkodie J.A, Edoh DA, Kretchy I.A., Aboagye F.A., Appiah A.A., Frimpong-Manso S., ASIEDU-GYEKE I.J., Nyarko A.K., Debrah P., Owusu-Donkor P. (2014).  Alternative therapy in Type 1 Diabetes: The effect of Croton Membranaceous extracts. International Journal of Chemistry and Pharmaceutical Sciences, 2(6), 883-889.

  • Awortwe C., ASIEDU-GYEKYE I.J., Nkansah E., Adjei S. (2014). Unsweetened natural cocoa powder has anti-asthmatic potential, International Journal of Immunopathology and Pharmacology, 27 (2), 2303-212.

  • Kukuia K.K.E., ASIEDU-GYEKYE I.J., Woode E., Addae E. (2014). Phytotherapy of experimental depression: Kalanchoe integra Var. Crenata (Andr.) cuf leaf extract. Journal of Pharmacy and Bioallied Sciences, 7 (1), 26-31.

  • ASIEDU-GYEKYE I.J., Antwi D.A., Awortwe C., N’guessan B.K., Nyarko A.K. (2014). Short term administration of Kalanchoe integra leaf extract produces no major organ damage in Sprague-Dawley rats. Journal of Ethnopharmacology, 151, 891-896. DOI:10.1016/J.JEP.2013.11.050.

  • Kukuia K.K.E., ASIEDU-GYEKYE I.J., Ameyaw E.O., Woode E., Mante P.K. (2014). Kalanchoe integra Var. Crenata (Andr.) Cuf Leaf Extract exhibits anticonvulsant effect in murine models: Enhancement of GABAergic, Glycinergic, and potassium ion conductance, Asian Journal of Biochemical and Pharmaceutical Research, 4(1), 43-54.

  • ASIEDU-GYEKYE I.J., Awortwe C., Antwi D.A., Nyarko A.K. (2014). Antidiabetic potential and accompanying histopathological changes of an Aqueous Leaf Extract of Kalanchoe integra Var.  Crenata (Andr.)  Cuf Leaves in genetic diabetic mice. International Journal of Pharmacy, Photon 105, 411-419.

  • ASIEDU-GYEKYE I.J., Awortwe C.,   Antwi D.A. (2014). Absence of visible toxic effects accompanying the short-term administration of an aqueous extract of Allium sativa Linn. in male Sprague-Dawley rats. American Journal of Pharmacology and Toxicology, 9(1), 53-67.

  • ASIEDU-GYEKYE I.J, Awortwe C., Nyamekye E.S., Antwi D.A., Seidu M.A., Adjei S., N’guessan B.B., Amoateng P., Nkansah E. (2014) Nutraceutical with anti-inflammatory activity for the management of airway remodeling in bronchial asthma: Kalanchoe integra leaf extract, Pharmacology and Pharmacy, 5, 250-261.

  • ASIEDU-GYEKYE I.J., Awortwe C, Antwi D.A. (2014). Supra-Supplementational levels of Dawadawa (Pakia biglobosa) powder has toxicity potential in Sprague-Dawley rats. The Journal of Toxicology and Health, Photon, 104, 395-405.

  • ASIEDU-GYEKYE I.J., Awortwe C., Tagoe B.N.A., Antwi D.A., Adjei S., Edusei D.I., N’guessan B.B., Amoateng P., Nkansah E. (2014). Preliminary investigation into the antiasthmatic potential of Kalanchoe integra leaf extract using a model of allergic airway inflammation, European Journal of Medicinal Plants, 4(5), 542-562.

  • Afriyie D.K., Asare G.A., Bugyei K., ASIEDU-GYEKYE I.J., Tackie R., Adjei S. (2013). Prostate specific targeting of the aqueous root extract of Croton membranaceous in experimental animals. Andrologia, 1-8.  doi: 10.1111/and.12144 [Epub ahead of print]

  • Antwi D. A., ASIEDU-GYEKYE I. J., Awortwe C., Adjei S., Addo P. (2013). Ansingle oral high dose toxicity study of Kalanchoe integra var. crenata (Andr.) Cuf leaf extract in ICR Mice: Histopathological and biochemical changes. International Journal of Medical and Pharmaceutical Sciences, 3 (9), 8-17.

  • ASIEDU-GYEKYE I.J., Antwi D.A, Bugyei K.A., Awortwe C. (2013). Vascular   effects of an aqueous extract of Kalanchoe integra var.crenata (Andr.)  Cuf leaves: Reversal of postischaemic dysautoregulation in a rat model of cerebral ischaemia, Journal of Physiology and Pharmacology Advances, 3(4), 103-109.

  • Awortwe C., Osei-Safo D., ASIEDU-GYEKYE I.J., Sackeyfio A.C. (2013). The anti-inflammatory activity of Taraxacum officinale leaves in ovalbumin-sensitized guinea-pigs. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (2), 628-633.

  • Asare G.A., Bugyei K., Fiawoyi I., ASIEDU-GYEKYE I.J., Gyan B., Adjei S., Addo P., Otu-Nyarko L., Nyarko A.K. (2013). Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthus niruri. Pharmaceutical Biology, 1-9.

  • Afriyie D., Asare G., Bugyei K.A., ASIEDU-GYEKYE I.J., Addo P., Adjei S., Sittie A.A., Nyarko A.K. (2013). Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies. Pharmacognosy Research, 5(1), 10-16.

  • ASIEDU-GYEKYE I.J., Antwi D.A., Awortwe C., Bugyei K. (2012). Comparative study of two Kalanchoe species: Total flavonoid, phenolic contents and antioxidant properties. African Journal of Pure and Applied Chemistry (AJPAC), 6 (65), 65-73.

  • Awortwe C., Sackeyfio A.C., Osei-Safo D., Bugyei K.A., ASIEDU-GYEKYE I.J. (2011). Dual effect of Taraxacum officinale leaves: Anticholinergic and inhibitory effect on inflammatory cells in ovalbumin-sensitized guinea-pigs. African Journal of Pharmacy and Pharmacology, 5 (23), 2613-2619. DOI:10.5897/AJPP11.616, ISSN 1996-0816.