The bioinformatics course provides computational methods and development of algorithms to address problems in molecular biology. Topics include molecular genetics of DNA, RNA and protein, cellular organization, modern biochemical techniques such as cloning and DNA sequencing, bioinformatics problems, bioinformatics database, representing and retrieval of sequences, sequence comparison with dot matrices and dynamic programming, statistics of pattern appearance, multiple sequence alignment, sequence database searching, learning machine basics, phylogenetic tree construction and algorithms, representing and finding sequence features, RNA and protein structure prediction, gene prediction and annotation, gene finding, retrieving and displaying macromolecular structures, microarrays and gene expression analysis models and technologies, biomolecular computing.