Dr. Mahmood Abdulai Seidu ((HNC (Medical Laboratory Science), UWE, MPhil (Pathology), UG, Ghana PhD (Pathology)), UG, Ghana England BSc (Biomedical Science), UWE, England)

Research profile or Interest (Details of Research or Major Projects Undertaken):

Worked as a career researcher in a WHO sponsored Onchocerciasis Chemotherapy Research Center (OCRC) in Tamale and later in Hohoe for 23 years where he performed various laboratory analyses in parasitology, haematology, clinical chemistry, cellular pathology and in-vitro studies relating to the efficacy of drugs on Onchocerca volvulus.

Now teaches pathology related subjects in the Department of Medical Laboratory Sciences of the University of Ghana, School of Biomedical and Allied Health Sciences in Korle-Bu Teaching Hospital, Accra, Ghana.

Conducted and/or participated in various projects including: Antigen retrieval in Immunohistochemistry (1994), Assessment of the viability of adult O. volvulus in tissue sections using enzyme histochemical demonstration of LDH activity (2003), Studies on energy pathways available to adult O. volvulus using immunohistochemical techniques (2010). African Women and Cervical Cancer (April 2008 to April 2010), DEC patch test for detection of onchocerciasis infection (2012)

Current Research Interests

Cytogenetics: 1. Chorionic villus sampling for diagnosis of genetic diseases of unborn babies. 2. Genetic diseases and detection systems.

Tissue and parasite interrelations: studies on tissue parasites and host interrelations using histochemical demonstration methods.

Technical reviews on various histochemical techniques (histological stains, Immunohistochemistry, enzyme histochemistry, in-situ hybridization etc)

Investigation of dye properties of some local herbs. Cola, Dawadawa etc

PROFESSIONAL AND ACADEMIC SHORT TERM COURSES ATTENDED      

1. January – April, 2021: CANCER GENOME PROJECT GHANA, Systemic Effects of Cancer: Cancer Genome and Beyond. A COURSE IN CANCER GENOMICS
2. 15 -17^th November 2005. workshop on lesson planning, classroom management and assessments, organized by University of Education, Wineba at School of Allied Health sciences, University of Ghana. (certificate available)
3. November 1996 – December 1996: Training on histological examination of O. volvulus nodules for drug assessment including immunohistology and PCR at Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, (Bernhard Nocht Institute –Visiting scientist grant).
4. October 1994 – December 1994: Training in In-vitro drug trials on tropical parasites at the International Institute of Parasitology (IIP), St Albans, Near London. (Sponsor: WHO- Special Training and Research in Tropical diseases)

Selected Publications

Margaret Kweku, Dongmei Liu, Martin Adjuik, Fred Binka, Mahmood Seidu, Brian Greenwood, Daniel Chandramohan. Seasonal Intermittent Preventive Treatment for the Prevention of Anaemia and Malaria in Ghanaian Children: A Randomized, Placebo Controlled Trial. PLoS ONE Vol. 3 No. 12, 2008

M. A. Seidu, A. R. Adams, R. K. Gyasi, Y. Tettey, E. K. Wiredu.  (2012). Short time incubation at low temperature for retrieval of some antigens from formalin-fixed and paraffin-embedded tissues. Journal of Histotechnology; Vol. 35 No. 2, 2012,  p74-79

M. A. Seidu, A.R. Adams, R.K. Gyasi, Y. Tettey, D.O. Nkansh, E.K. Wiredu.  (2013). Immunoreactivity of some epitopes in longtime inappropriately stored paraffin embedded Tissues. Journal of Histotechnology. Vol. 36 No. 2, 2013, pp 59-64

Asiedu-Gyekye Isaac Julius, Awortwe Charles, Nyamekye Effah Samuel, Antwi Daniel Ansong, Seidu Mahmood, Adjei Samuel, Banga N’guessan Benoit Kwame, Amoateng Patrick, Nkansah Edwin. (2014). Nutraceutical with Anti-Inflammatory Activity for the Management of Airway Remodeling in Bronchial Asthma: Kalanchoe integra Var. Crenata (Andr.) Cuf Leaf Extract. Pharmacology & Pharmacy, 5, (2014) 250-261.

Seidu Mahmood Abdulai, Adams Abdul Rashid, Gyasi Kwame Richard, Tettey Yao, Nkansah Obenewaa Dinah, Adunyame Lois, Wiredu Kwame Edwin. (2014). Immunohistochemical Study on lipid Catabolism in Adult Onchocerca Volvulus. American Journal of Biomedical and Life Sciences. Vol. 2, No. 4, 2014, pp. 65-69. doi: 10.11648/j.ajbls.20140204.11

George Awuku Asare, Dan Afriyie, Robert A. Ngala, Harry Abutiate, Derek Doku, Seidu A. Mahmood and Habibur. (2014). Antiproliferative Activity of Aqueous Leaf Extract of Annona muricata L. on the Prostate, BPH-1 Cells, and Some Target Genes. Integr Cancer Ther published online 18 November 2014 DOI: 10.1177/1534735414550198

Samuel S. Antwi-Baffour1, Ransford Kyeremeh1, Alhassan Shaibu2, Jonathan Adjei1, Mahmood S. Abdulai1 Storage of Blood for Transfusion in Domestic Refrigerators: Any Immune  Consequences?

Benoit Banga N’guessan a,*, Seth Kwabena Amponsah a,1, Ifeanyichukwu Benedict Iheagwara a, Mahmood Abdulai Seidu b, Samuel Frimpong-Manso c, Ebenezer Ofori-Attah e, Emelia Oppong Bekoe d, Joseph Adusei Sarkodie d, Regina Appiah-Opong e,Isaac Julius Asiedu-Gyekye a (2021). Toxicity, mutagenicity and trace metal constituent of Termitomyces schimperi (Pat.) R. Heim (Lyophyllaceae) and kaolin, a recipe used traditionally in cancer management in Cote d’Ivoire Journal of Ethnopharmacology. journal homepage: www.elsevier.com/locate/jethpharm.

Benjamin Arko-Boham ,1,2 Bright Afriyie Owusu,1 Nii Ayite Aryee,3 Richard Michael Blay,2 Ewurama Dedea Ampadu Owusu,1,4,5 Emmanuel Ayitey Tagoe,1,6 Abdul Rashid Adams,1 Richard Kwasi Gyasi,7 Nii Armah Adu-Aryee,8,9 and Seidu Mahmood,1 (2020). Prospecting for Breast Cancer Blood Biomarkers: Death-Associated Protein Kinase 1 (DAPK1) as a Potential Candidate. Hindawi Disease Markers, Volume 2020, Article ID 6848703, 7 pages https://doi.org/10.1155/2020/6848703

Samuel Antwi-Baffour ,1,2 Ransford Kyeremeh,1,3 Atta Poku Amoako,1 Lawrence Annison,2 John Ocquaye-Mensah Tetteh,3 and Mahmood Abdulai Seidu1.. (2019). The Incidence of Malaria Parasites in Screened Donor Blood for Transfusion. Hindawi Malaria Research and Treatment Volume 2019, Article ID 1457406, 6 pages https://doi.org/10.1155/2019/1457406

Obese, A. O., Obiri, D., Adams, R., & Seidu, M. A. (2019). Histological diagnosis of placental malaria in women with and without pre-eclampsia at the Korle-Bu Teaching Hospital. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health, 17, S22. https://doi.org/10.1016/j.preghy.2019.08.136

Samuel Antwi-Baffour ,1 Jonathan Kofi Adjei,1 Felix Tsyawo,2 Ransford Kyeremeh,1 Felix Abekah Botchway,3 and Mahmood Abdulai Seidu1 (2019). A Study of the Change in Sodium and Potassium Ion Concentrations in Stored Donor Blood and Their Effect on Electrolyte Balance of Recipients. BioMed Research International Volume 2019, Article ID 8162975, 5 pages https://doi.org/10.1155/2019/8162975

SamuelAntwi-Baffour,1,2 JonathanKofiAdjei,1 PeterOwadeeForson,2 StephenAkakpo,2 RansfordKyeremeh,1 and Mahmood Abdulai Seidu1 (2019). Comorbidity of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease Exert Significant Effect on RBC Indices. Volume 2019, Article ID 3179173, 9 pages https://doi.org/10.1155/2019/3179173

Samuel Antwi‑Baffour1*, Ransford Kyeremeh1,2, Dorcas Buabeng1,4, Jonathan Kofi Adjei1,3, Claudia Aryeh1, George Kpentey2 and Mahmood Abdulai Seidu1,4 (2018). Correlation of malaria parasitaemia with peripheral blood monocyte to lymphocyte ratio as indicator of susceptibility to severe malaria in Ghanaian children

Mahmood Abdulai Seidu1*, Eric Yeboah3, A. R. Adams1, D.O. Nkansah1, L. Adunyame1, Cecilia Krampah1 and R. K. Gyasi2 (2017). Effects of Clearing Agents on the Detection of Acid Fast Bacilli in Paraffin Embedded Lung Tissues. Journal of Infectious Disease and Immunology. Nessa Pubishers,Volume 1| Issue 3

Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo, Believe Ahedor, Seidu A. Mahmood, Benoit B. N’guessan, Isaac J. Asiedu-Gyekye, Alexander K. Nyarko. (2016). Long-term continuous administration of a hydro-ethanolic extract of Synedrella nodiflora (L) Gaertn in male Sprague-Dawley rats: biochemical, haematological and histopathological changes. Ghana Med J; 50(3): 163-171 DOI: http://dx.doi.org/10.4314/gmj.v50i3.8

Isaac Julius Asiedu-Gyekye, Mahmood Abdulai Seidu, Banga Benoit N’guessan, Samuel Frimpong–Manso, Joseph Edusei Sarkodie, Samuel Adjei, Schevadnazy Kutu, Joseph Osei-Little, Alexander Kwadwo Nyarko and Philip Debrah. 2016. A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity. BMC Complementary and Alternative Medicine (2016) 16:348 DOI 10.1186/s12906-016-1334-3

Isaac Julius Asiedu-Gyekye, Kennedy Kwami Edem Kukuia, Abdulai Mahmood Seidu, Charles Antwi-Boasiako, Benoit Banga N’guessan, Samuel Frimpong-Manso, Samuel Adjei, Jonathan Zobi, Abraham Terkpertey Tettey, and Alexander Kwadwo Nyarko. (2016). Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs. Evidence-Based Complementary and Alternative Medicine Volume 2016, Article ID 7387286, 11 pages http://dx.doi.org/10.1155/2016/7387286

Seidu Mahmood Abdulai, Adams Abdul Rashid, Gyasi Kwame Richard, Tettey Yao, Adunyame Lois, Nkansah Obenewaa Dinah, Wiredu Kwame Edwin. (2016) Carbohydrate Catabolism in Adult Onchocerca volvulus: An Immunohistochemical Study. American Journal of Biomedical and Life Sciences. Vol. 4, No. 3, 2016, pp. 35-40. doi: 10.11648/j.ajbls.20160403.13

Isaac J. ASIEDU-GYEKYE, Abdulai Seidu MAHMOOD, Charles AWORTWE, Alexander K. NYARKO. (2015). Toxicological assessment of polyhexamethylene biguanide for water treatment. Interdiscip Toxicol. 2015; Vol. 8(4): 193–202. doi: 10.1515/intox-2015-0029

Samuel Antwi-Baffour, Jonathan Adjei, Claudia Aryeh, Ransford Kyeremeh, Foster Kyei and Mahmood A. Seidu. (2015). Understanding the Biosynthesis of Platelets-derived Extracellular Vesicles. Immunity, Inflammation and Diseases, 3(3):133–140.  doi:10.1002/iid3.66

Samuel Antwi-Baffour, Ransford Kyeremeh, Alexander Martin-Odoom, Mahmood A. Seidu and Patrick F Ayeh-Kumi.  (2015). Biological functions of Plasma Membrane-derived Extracellular Vesicles and their role in Diseases. Journal of Cells, 1(3): 33 – 42.

Antwi-Baffour, S. S., Kyeremeh, R., Shaibu, A., Adjei, J. and Abdulai, M. S. (2015). Storage of Blood for Transfusion in Domestic Refrigerators: Any Immune Consequences? Open Access Library Journal, 2, e1909. doi.org/10.4236/oalib.1101909.

FELLOWSHIPS

1. College of Health Sciences, post graduate endowment fund; Bench fees. 8^th May, 2008. Amt. GHc 2,000.00
2. University of Ghana Fellowship 09/10/2007. Amount GHc 8,000.00
3. WHO- Special Training and Research in Tropical diseases grant, 1994: training in In-vitro drug trials on tropical parasites at the International Institute of Parasitology (IIP), St Albans, Near London. 1994  
4. Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, (Bernhard Nocht Institute –Visiting scientist grant). 1996

BOOKS

Abdulai Mahmood Seidu. (2013). Immunohistochemical study on metabolism in adult Onchocerca volvulus. Publishers: LAP Lambert Academic publishing, Germany. ISBN - 13: 978-3-659-35834-0 ISBN – 10:3659358347

BOOK CHAPTERS

G. Asare, MM Addae and MA Seidu (2014). Provision of Specialized Medical Laboratory Service to the Public – The Future. In Contributions of Allied Health Sciences to Healthcare Delivery in Ghana. University of Ghana Readers: Chapter 6; Pages 79–110. Editors: Samuel Antwi-Baffour, Patrick Ayeh-Kumi, Ajadiran I. Bello, Samuel Anim-Sampong, Eric Ofori, Laurene Boateng and Peter Ndaa. Publishers: Digibooks Ghana Ltd. P. O. Box BT1 Tema, Ghana. ISBN: 978-9988-2-0150-0