BCMB 415: XENOBIOTIC METABOLISM

Pathways of xenobiotic metabolism; Phase I and II reactions.  Enzymology and molecular mechanisms of xenobiotic metabolism; cytochrome P-450-dependent mixed-function oxidation reactions, microsomal flavin-containing monooxygenases, prostaglandin synthetase, reduction enzymes, epoxide hydrolase and conjugating enzymes.  Factors affecting xenobiotic metabolism; internal and external.  Pharmacological and toxicological aspects of xenobiotic metabolism - Pharmacological; activation and deactivation, changes in pharmacological response, drug uptake and distribution, enterohepatic circulation.  Toxicological; metabolic activation (increased toxicity) - carcinogenesis, mutagenesis, teratogenesis, pulmonary, hepatic and renal toxicities.  Deactivation (decreased toxicity).  Balance between toxification and detoxifying pathways.