BCMB 406: MOLECULAR GENETICS

Genetic Foundations: Overview of Mendelian and non-Mendelian inheritance, Transformation, transduction, and conjugation, Recombination and complementation, Mutational analysis, Genetic mapping and linkage, Analysis.

Chromatin and Chromosomes: Overview of Karyotypes, Translocations, inversions, deletions, and duplications, Aneuploidy and polyploidy Structure.

Genomics: Genome structure, Physical mapping, Repeated DNA and gene families, Gene identification, Transposable elements,

Genome Maintenance: DNA replication, DNA damage and repair, DNA modification, DNA recombination and gene conversion.

Gene Regulation in Eukaryotes: Cis-acting regulatory elements, Trans-acting regulatory factors, Gene rearrangements and amplifications, Genetic manipulation of bacteria: transposons and plasmids. Large scale genome analysis: the human genome project.