BCMB 306: INTEGRATION AND CONTROL OF METABOLISM

Metabolic control: Design of metabolic pathways. Regulatory enzymes fine control (allosteric, substrate/product feed- back and feed-forward controls, covalent modification) and coarse control (induction and repression of enzyme synthesis).  

Regulation of fuel metabolism: glycolysis, gluconeogenesis, glyceroneogenesis, glycogenolysis and glycogenesis, Krebs cycle, lipogenesis and lipolysis, β-oxidation, ketogenesis, amino acid metabolism. Role of hormones (e. g. insulin, glucagon, epinephrine) and DNA binding proteins (e. g. Cyclic AMP response element binding protein (CREB), Carbohydrate response element binding protein (ChREBP), Sterol regulatory element binding protein (STREB)). 

Integration of metabolism: Glucose homeostasis and glucose transpoters. Interrelationships between carbohydrate, lipid, and protein metabolism. Enzyme profiles of tissues and organs. Interorgan relationships (liver, brain, muscle, adipose tissue) in different physiological states: e. g. Fed, fasted, running athlete and pregnancy.