PHAR 221 Pharmaceutical Microbiology II

This course will make students aware of the significance and implications of microbial contamination of

pharmaceutical products and the need for disinfection and sterilization. Methods of Sterilization will

cover dry heat; moist heat (autoclave-various types); Heating with a bactericide (HWAB); Filtration

(various types); High efficiency particulate air filters (HEPA filters); Testing of filters. Gaseous

sterilization, ethylene oxide sterilization. Radiation sterilization. Monitoring of sterilization efficiency by

physical, chemical and bacteriological methods. The course will also cover Principles of Disinfection and

discuss types of disinfectants; dynamics of disinfection; factors influencing efficiency of disinfection

process; evaluation of disinfectant activity. The topic of Preservation will be covered and will cover the basic principles; types; reservation of sterile pharmaceutical products