Jonathan P. Adjimani (BSc (Kumasi), MSc (Brock), PhD (Utah State))

RESEARCH INTEREST(S)

• Iron chelators as antiviral, antimicrobial, antitumor, anti-inflammatory agents.

• Scientific basis for therapeutic action of medicinal plants.

• Isolation and characterization of natural products with nutraceuticals and cosmeceutical value.

Natural phenolic compounds of plant origin such as benzoic acids and cinnamic acid derivatives, belonging to non-flavonoid polyphenols have been shown to possess several pharmacological properties including antiviral, antimicrobial, antitumor, anti-inflammatory, etc. Not much has been studied about the iron chelating potential of these compounds and how this relates to their pharmacological properties. My interest is in evaluating the iron chelating properties of these compounds and their possible use as antimalarials, antitumor, anti-inflammatory, antiviral, or antimicrobial agents. Their structural relatedness should enable us understand any structure-activity relationships that may be important for these pharmacological activities.

SELECTED PUBLICATIONS

1. Adjimani, J.P., Asare, P. (2015). Antioxidant and free radical scavenging activity of iron chelators. Toxicology Reports (2) 712-718.

2. Asiedu-Larbi, J, Adjimani, J., Okine, L.K.N., Addy, M.E., Nyarko. A. K. (2014). Efficacy studies on Mist Diodia, a herbal preparation for the management of hypertension in rodents. Medicinal and Aromatic Plant Research Journal. 2: 6-17

3. Sakyiamah, M. M., Ocloo, A., Adjimani, J. P. and Sittie, A. A. (2012): Effect of aqueous extract of cryptolepis sanguinolenta on the pharmacokinetics of chloroquine. International Journal of Drug Research and Technology 2 (4S), 378-387

4. Ocloo, A., Sakyiamah, M. M., Adjimani, J. P. and Sittie, A. A (2012): Aqueous extract of Cryptolepis sanguinolenta enhance cytochrome P450 1A isozyme activity in presence of Atesunate. Global Journal of Medical Research 12(5): 15 – 21

5. Sakyiamah, M. M., Ocloo, A., Adjimani, J. P. and Sittie, A. A. (2011): Effect of aqueous extract of cryptolepis sanguinolenta on the pharmacokinetics of Artesunate. International Journal of Pharmaceutical and Drug Research 3(4): 313 – 318

6. Adinortey, M. B, Gyan, B. E., Adjimani, J. P., Nyarko, P., Sarpong, C., Tsikata, F. Y. and Nyarko, A. K. (2011).Haptoglobin polymorphism and association with complications in Type 2 diabetic patients. Ind.  J. Clin. Biochem. 26:366-372

7. Adinortey, M. B, Gyan, B. E., Adjimani, J. P., Nyarko, P., Sarpong, C., Tsikata, F. Y. and Nyarko, A. K. (2011).  Dyslipdaemia associated with Type 2 diabetes with micro and macrovascular complications among Ghanaians. Ind. J. Clin. Biochem. 26:261-268

8. Dongdem,  J. T., Adjimani, J. P.,   and Armah, G. (2010) Detection and characterization of human rotavirus in tap water by multiplex RT-PCR. J. Med. Sci. 1: 223-230

9. Kusi K.A, Gyan B.A, Goka B.Q, Dodoo D, Obeng-Adjei G, Troye-Blomberg M, Akanmori B.D, Adjimani J. P. (2008).  Levels of soluble CD163 and severity of malaria in children in Ghana.Clin Vaccine Immunol. 15:1456-60.