The Department was established in 1963 as part of the erstwhile Department of Biochemistry, Nutrition and Food Science (BNFS) and housed in the Department of Animal Science in the then Faculty of Agriculture. In 1967, the BNFS moved from Department of Animal Science to the present Nutrition and Food Science building. The Department then in 1970 span from BNFS to the Department of Biochemistry, headed by Prof. George Stephen Asante and was housed in a temporary building for 30 years. In 2010 the Department comprehensively reviewed its programme and adopted its current name; Department of Biochemistry, Cell and Molecular Biology to reflect the content of its new curriculum. The Department is currently housed in the Central Science Building of the Faculty of Science and has two teaching laboratories and six offices for lecturers on the second floor, four research laboratories, head of department office, administration and four offices on the first floor, a library and staff common room on the ground floor. There are also a number of technician offices.