Osbourne Quaye (BSc (Ghana), MSc, PhD (Georgia))

RESEARCH INTEREST

1. Zoonotic transmission of gastro-viral agents and the effect of animal gastro-viruses, such as rotavirus, on vaccine development and efficacy.

2. Discovery and characterization of medicinal plants as anti-gastro-viral agents.

3. Identification and characterization of flavin-dependent enzymes in infectious disease agents as probable/potential drug targets.

AREA OF SPECIALIZATION

Zoonotic transmission of gastro-viral agents, Virology,

ON-GOING RESEARCH PROJECTS

• Contribution of strain diversity to rotavirus vaccine effectiveness in Ghana: Investigating human rotavirus reservations and strain diversity in farm animals.
• Impact of oxidative stress on HIV-AIDS progression in Ghanaian patients.
• Preliminary molecular characterization of human gastroviral agents with in the Ashaiman Municipality of the Greater Accra Region of Ghana.

SELECTED PUBLICATIONS

1. Kuleape, J. A., Tagoe, E. A., Puplampu, P., Bonney, E. Y., Quaye, O., (2018), Homozygous deletion of both GSTM1 and GSTT1 genes is associated with higher CD4+T cell counts in Ghanaian HIV Patients, PLos ONE 13(5): e0195954. https://doi.org/10.1371/journal.pone.0195954
2. Quaye, O., Roy, S., Rungsrisuriyachai, K., Esona, M. D., Xu, Z., Tam, K. L., Banegas, D. J. C., Rey-Benito, G., Bowen, M. D., (2018), Second-line anti-tuberculosis drug resistance testing in Ghana identifies the first extensively drug-resistant tuberculosis case, Infection and Drug Resistance, 2018(11):239-246 doi:20.2147/IDR.S152720.
3. Mijatovic-Rustempasic, S., Tam, K. I., Kerin, T. K., Lewis, J. M., Gautam, R., Quaye, O., Gentsch, J. R. and Bowen, M. D. (2013); Sensitive and Specific Quantitative Detection of Rotavirus A by One-Step Real-Time Reverse Transcription PCR Assay without Antecedent dsRNA Denaturation; Journal of Clinical Microbiology, 51(9): 3047-3054.

2. Quaye, O., McDonald, S., Esona, M., Lyde, F., Gentsch, J. and Bowen, M. (2013); Detection of rotavirus G9P[4] strains in three Latin America Countries; Surveillance during the 2009-2010 rotavirus season; EmergingInfectious Diseases, 19(8): 1332-1333.
3. Gautam, R., Lyde, F., Esona, M. D., QuayeO., and Bowen, M. D.(2013); Comparison of PremierTMRotaclone®, ProSpecT™, and RIDASCREEN® Rotavirus Enzyme Immunoassay Kits for Detection of Rotavirus Antigen in Stool Specimens; Journal of Clinical Virology, 58(1): 292-294.
4. Patel, M.M., Patzi, M., Pastor, D., Nina, A., Roca, Y., Alvarez, L., Iniguez, V., Rivera, R., Tam, K.I., Quaye, O., Bowen, M., Parashar, U. and De Oliveira, L.H. (2013); Effectiveness of monovalent rotavirus vaccine in Bolivia: case-control study; British Medical Journal (Web Published).
5. Cortese, M.M., Immergluck, L.C., Held, M., Jain, S., Chan, T., Grizas, A.P., Khizer, S., Barrett, C., Quaye, O., Mijatovic-Rustemapasic, S., Gautam, R., Bowen, M.D., Moore, J., Tate, J.E., Parashar, U.D. and Vázquez, M. (2013) Effectiveness of monovalent and pentavalent rotavirus vaccines; Pediatrics, 132(1): 25-33.
6. Esona, M.D., Mijatovic-Rustempasic, S., Foytich, K., Roy, S., Banyai, K., Armah, G., Steele, A., Volotão, E., Gomez, M., Silva, M., Gautam, R., Quaye, O., Tam K, Forbi J, Seheri M, Page N, Nyangao J, Ndze V, Aminu M, Bowen M and Gentsch J. (2013); Human G9P[8] rotavirus strains circulating in Cameroon, 1999-2000: genetic relationships with other G9 strains and detection of a new G9 subtype; Infection, Genetics and Evolution, 18: 315-324.
7. Cardemil, C. V., Cortese, M. M., Medina-Marino, A., Jasuja, S., Desai, R. Leung, J. Rodriguez-Hart, C., Villaruel, G., Howland, J., Quaye, O. Tam, K. I., Bowen, M. D. Parashar, U., Gerber, S. and the Rotavirus Investigationteam (2012); Two rotavirus outbreaks caused by genotype G2P[4] at large retirement communities; Annals of Internal Medicine, 157(9): 621-631.
8. Boom, J. A., Tate, J. E., Sahni, L. C., Rench, M. A., Quaye, O., Mijatovic-Rustempasic, S., Patel M. M., Baker, C. J. and Parashar, U. D. (2010); Sustained protection from pentavalent rotavirus vaccination during the second year of life at a large, urban US pediatric hospital; Pediatric Infectious Disease Journal, 29(12) : 1133-1135.
9. Quaye, O., Nguyen, T. Gannavaram, S., Pennati, A. and Gadda, G. (2010); Rescuing of the hydride transfer reaction in the Glu312Asp variant of choline oxidase by a substrate analogue; Archives of Biochemistry and Biophysics, 499(1-2): 1-5.
10. Quaye, O. and Gadda, G. (2009); Effect of a conservative mutation of an active site residue involved in substrate binding on the hydride tunneling reaction catalyzed by choline oxidase; Archives of Biochemistry and Biophysics, 489(1-2): 10-14.
11. Quaye, O., Cowins, S. and Gadda, G. (2009); Contribution of flavin covalent linkage with His99 to the reaction catalyzed by choline oxidase; Journal of Biological Chemistry, 284(25): 16990-16997.
12. Quaye, O., Lountos, G. T., Fan, F., Orville, A. M. and Gadda, G. (2008); Role of Glu312 in binding and positioning of the substrate for the hydride transfer reaction in choline oxidase; Biochemistry, 47(1): 243-256.