Lydia Mosi (BSc (Ghana), PhD (Tenn))

RESEARCH INTEREST

My research interest is with Buruli ulcer, a necrotizing skin ulcerative disease caused by Mycobacterium ulcerans. I am interested in investigating the existing gaps in transmission by exploiting multidisciplinary approaches that will aid in identifying the niche of the bacterium in the natural environment; using in silico genomics and functional laboratory studies to provide insight into the environmental niche of M. ulcerans and other environmental mycobacteria; and the development of rapid diagnostic and intervention strategies for Buruli ulcer disease.

AREA OF SPECIALIZATION

Microbiology, Molecular Biology and Bioinformatics

ON-GOING RESEARCH PROJECTS

1. TWAS - The World Academy of Sciences for the Advancement of Science in Developing Countries – Functional classification of selected oxidate stress response pseudogenes in Mycobacterium ulcerans with respect to acquisition of mycolactone producing plasmid.
2. International Foundation for Science (IFS) Collaborative Research Grants – Assessing the efficacy of kombucha, and fungal extracts on inactivating mycolactone produced by Mycobacterium ulcerans. - 2013-2015
3. University of Ghana Research Fund. “Microbiology of Secondary infections in Buruli ulcer lesions; Implications for Therapeutic interventions”; 2013-2014
4. Afrique One Wellcome Trust  - Afrique One Post doctoral fellowship under Wellcome Trust; Centre Suisse de Recherche Scientifique in Cote d’Ivoire. January 2011-2014

RECENT PUBLICATIONS

1. Addo, K. K., Addo, S. O., Mensah, G. I., Mosi, L., Bonsu, F. A., (2017). Genotyping and drug susceptibility testing of mycobacterial isolates from populaion-based tuberculosis prevalence survey in Ghana, BMC Infectious Diseases, 17:743 , DOI 10.1186/s12879-017-2853-3
2. Narh C. A. , Mosi L., Quaye C., Tay S.C.K, Bonfoh B., de Souza D. K.. 2014. Genotyping tools for Mycobacterium ulcerans- drawbacks and future prospect. Mycobact Dis; 4(2):1000149.
3. Williamson H.R., Aqqad M., Donnell R., Mosi L., and Small P.L.C.  2014 Laboratory Studies on the ability of Mycobacterium ulcerans to infect through open wounds. PLoS Negl Trop Dis.; 8(4):e2770
4. Mosi L., Mutoji N., Basile F. A. , Donnell R., Jackson K. L., Spangenberg T., Kishi Y., Ennis D.,  and Small P. L.C. 2012 Experimental infection of Medaka (Oryzias latipes) with Mycobacterium ulcerans: A model for transmission, pathogeneses and toxicity to fish. Microb. and infect.; 14(9):719-29.
5. Wilson M. D, Boakye D. A., Mosi L., Asiedu K. 2012. In the case of transmission of Mycobacterium ulcerans in Buruli ulcer disease Acanthamoeba species stand accused. Ghana Med. J. 45(1): 31-34.
6. de Souza D. K., Quaye C., Mosi L., Addo P., Boakye D. A. 2012. A quick and cost effective method for the diagnosis of Mycobacterium ulcerans infection. BMC Infect Dis. 12:8. doi: 10.1186/1471-2334-12-18.
7. Wallace J. R., Gordon M. C., Hartsell L., Mosi L., Benbow E. M., Merritt R. W., Small P.L.C. 2010. Survival of Mycobacterium ulcerans within Mosquito species and preliminary implications for trophic relationships. Appl Environ Microbiol.; 76(18):6215-6222.
8. Kim HJ, Jackson KL, Kishi Y, Williamson HR, Mosi L, Small PL. 2009.Heterogeneity in the stereochemistry of mycolactones isolated from M. marinum: toxins produced by fresh vs. saltwater fish pathogens. Chem Commun (Camb).;( 47):7402-7404.
9. Mosi L, Williamson H, Wallace JR, Merritt RW, Small PL. 2008. Persistent association of Mycobacterium ulcerans with the West African predaceous insect, Belostomatidae. Appl Environ Microbiol.; 74(22):7036-7042.
10. Ranger B. S., Mahrous E. A., Mosi L., Adusumilli S., Lee R. E., Colorni A., Rhodes M., and Small P. L.C. 2006. Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F.  Inf And Imm.; 74(11):6037-6045