This comprehensive course delves into the fascinating world of aromatic compounds, a class of organic molecules renowned for their unique stability and diverse applications.

  • The Essence of Aromaticity: We begin by exploring the concept of aromaticity, delving into the electronic and structural characteristics that govern aromatic character. Explore the Hückel's rule and its implications for aromatic stability.
  • Visualization Tools: Learn to utilize molecular orbital theory and resonance structures to visualize the delocalized electron cloud that is a hallmark of aromatic compounds.
  • Non-benzenoid Aromatic Systems: Discover that aromaticity extends beyond benzene! Explore various heterocyclic and polycyclic aromatic compounds that exhibit aromatic character.
  • Electrophilic Aromatic Substitution (EAS): Uncover the fundamental mechanism of EAS reactions, the workhorse for introducing new functional groups onto aromatic rings. Analyze the role of Lewis acids as catalysts and explore the factors that influence the regioselectivity (position of substitution) and reactivity of different aromatic substrates.
  • Synthetic Applications of EAS: Witness the power of EAS reactions in organic synthesis. Learn how to prepare a diverse array of aromatic compounds with valuable functionalities like halides, nitro groups, alkyl groups, and more. Explore the applications of these compounds in pharmaceuticals, dyes, and polymers.
  • Nucleophilic Aromatic Substitution (NAS): While less common than EAS, delve into the mechanisms of NAS reactions and the conditions required for successful substitution. Explore the reactivity of different nucleophiles with aromatic rings.
  • Synthesis Strategies: Explore various methods for constructing polynuclear aromatic compounds, including coupling reactions, cyclization reactions, and condensation reactions.
  • Reactivity of Polynuclear Aromatic Compounds: Learn how the presence of multiple aromatic rings influences the reactivity of these complex molecules. Explore their unique properties and potential applications in materials science and organic electronics.
3
CHEM 343