MCBI 604: Host and Pathogen Genomics


This course aims to introduce students to the principles and tools for genomic and proteomic study of host-pathogen interactions. To that end it will discuss the content of multiple genomes elucidating their functions and organization. The course will also develop the modern, computer-based subjects of transcriptomics/metabolomics and the functional genomics of bacterial, viral and eukaryotic pathogens. Classical and complex disease genetics and quantitative trait locus (QTL) analysis, natural selection of pathogens, comparative genomics, genome wide association studies, genetic manipulations, computational learning (genome databases, modern methods for DNA sequencing, assembling pathogen genome sequences, genome-wide sequence read mapping and variant calling) will be discussed.